Rosie O'Donnell Responds to Trump's AI Deepfake Video Mocking 'Trump Derangement Syndrome' -…

In July 2026, a viral AI-generated video featuring Donald Trump as "Dr. Trump" surfaced, portraying various celebrities discussing their supposed recovery from "Trump Derangement Syndrome." The video utilized deepfake technology to depict Rosie O'Donnell, John Leguizamo, Whoopi Goldberg, Robert De Niro, Edward Norton, and Julia Roberts providing faux testimonials about their condition.

What happened

The video, structured as an infomercial, features an AI-generated version of Donald Trump offering a "treatment plan" for TDS, which includes turning off fake news, saying prayers, and drinking a Diet Coke. The clip then cuts to synthesized versions of several Hollywood stars making scripted admissions about their symptoms and relief. The deepfake of Rosie O'Donnell is the first to appear, claiming she has been suffering for over a decade. Other celebrities are shown making similar statements about being "lost causes" before finding help through the president's video.

The real Rosie O'Donnell responded to the clip on Instagram, calling for the president to be removed, impeached, and convicted under the 25th Amendment. Her post included a screenshot of the video and a comment referencing a potential lawsuit. While fans and supporters, including actress Alexandra Billings and psychologist Dr. Leslie Dobson, have encouraged O'Donnell to pursue legal action, there has been no official confirmation as of early July 2026 that any of the featured celebrities have initiated a lawsuit. The video has drawn a polarized public reaction, with some social media users praising the AI content while others express concerns regarding the nature of the deepfake.